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Accelerating personalized medicine.

Cytogenetic analysis of CTCs provides information regarding diagnosis, prognosis and therapeutic surveillance of cancer patients. We have developed DNA Fluorescence in situ Hybridization (FISH) assays to cytogenetically analyze CTCs downstream of enrichment from whole blood of patients. Isolated cells are first immunophenotyped to identify CTCs and then CTCs are relocated after target-specific FISH analysis has been performed.

  • FISH in CTCs, CECs, FFPE, frozen tissue, and bone
  • Custom FISH probe design
  • Commercially available FISH assays
  • Proprietary disease-specific FISH panels

  •       HER-2                   PTEN
          c-Met                      EGFR
          AR                          TMPRSS2-ERG
          EML4-ALK             IGF1-R

    Work flow for CTC identification for FISH and representative immunofluorescence images of CTC immunophenotyping based on Cytokeratin, CD45 and DAPI staining.

    Fluorescence In Situ Hybridization (FISH)

    Fluorescence In Situ Hybridization (FISH)